Thymosin beta 4 compositions and methods

A composition comprising a polypeptide agent comprising at least one of amino acid sequence LKKTET [SEQ ID NO:1] or a conservative variant thereof, gelsolin, vitamin D binding protein (DBP), profilin, cofilin, depactin, Dnasel, villin, fragmin, severin, capping protein, beta-actinin, acumentin, TB4, a TB4 isoform, a functional fragment of TB4 or a TB4 isoform having biological activity of TB4 or a TB4 isoform, TB4ala, TB9, TB10, TB11, TB12, TB13, TB14, or TB15, the composition further comprising a carrier for application to a surface of human body, wherein said carrier is for application to an external surface of said body or to an internal surface of said body, the composition comprising a gel, cream, paste, lotion, spray, suspension, dispersion, salve, hydrogel, tablet, or capsule, ointment, wherein said polypeptide is at a concentration in said carrier equivalent to at least about 0.01 ng/ml, and up to about 60 micrograms per 300 microliter.

A method of treatment for treating or preventing damage or injury to skin, dermal or epidermal tissue or portion of said tissue, for promoting regeneration of skin, or for inducing an epidermal cellular mechanism or process for formation or maintenance of an epidermal tissue or portion thereof, the method comprising contacting said skin, tissue or portion of said tissue with a composition comprising an agent comprising at least one of a polypeptide comprising amino acid sequence LKKTET [SEQ ID NO:1] or a conservative variant thereof, gelsolin, vitamin D binding protein (DBP), profilin, cofilin, depactin, Dnasel, villin, fragmin, severin, capping protein, beta-actinin, acumentin, TB4, a TB4 isoform, a functional fragment of TB4 or a TB4 isoform having biological activity of TB4 or a TB4 isoform, TB4ala, TB9, TB10, TB11, TB12, TB13, TB14, or TB15.