Novel Hemopoietin Receptor Protein, NR12
AssigneeChugai Seiyaku Kabushiki Kaisha, a Japan corporation
InventorsMasatsugu Maeda, Noriko Yaguchi
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Abstract
A novel hemopoietin receptor gene (NR12) was successfully isolated by extracting motifs conserved among the amino acid sequences of known hemopoietin receptors and by using the predicted sequence. The NR12 gene encodes two forms of proteins, a transmembrane type and a soluble type. The expression of the NR12 gene was detected in tissues containing hematopoietic cells. NR12 is a novel hemopoietin receptor molecule involved in the regulation of immune system and hematopoiesis in vivo. Thus, NR12 is useful in the search for novel hematopoietic factors that functionally bind to the NR12 receptor, and in the development of therapeutic drugs for diseases associated with immunity or hematopoiesis.
Claims21
A substantially purified polypeptide comprising the amino acid sequence from Gly at position 24 to Lys at position 629 of SEQ ID NO:10.
A substantially purified polypeptide comprising the amino acid sequence from Gly at position 24 to Lys at position 629 of SEQ ID NO:10 in which 1 to 10 amino acids are substituted, deleted, inserted, and/or added, wherein the polypeptide (a) comprises a WS motif identical to the sequence from Trp at position 304 to Ser at position 308 of SEQ ID NO:10, and (b) binds a hematopoietic factor.
A substantially purified polypeptide comprising the amino acid sequence of SEQ ID NO:10.
A substantially purified polypeptide comprising an amino acid sequence that is at least 70% identical to the amino acid sequence of SEQ ID NO:10, wherein the polypeptide (a) comprises a WS motif identical to the sequence from Trp at position 304 to Ser at position 308 of SEQ ID NO:10, and (b) binds a hematopoietic factor.
A substantially purified polypeptide encoded by a nucleic acid that hybridizes at wash conditions of 2×SSC and 0.1% SDS at 65° C. with a nucleic acid consisting of the complement of the coding region of SEQ ID NO:9, wherein the polypeptide (a) comprises a WS motif identical to the sequence from Trp at position 304 to Ser at position 308 of SEQ ID NO:10, and (b) binds a hematopoietic factor.
A substantially purified polypeptide comprising an immunogenic fragment of the amino acid sequence of SEQ ID NO:10, the fragment comprising more than nine consecutive residues of SEQ ID NO:10.
Dependencies are inferred from the claim text.