Neovascularization Inhibitors Derived From HGF and Methods Involving the Same
AssigneeToshikazu Nakamura
InventorToshikazu Nakamura
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Abstract
Novel neovascularization inhibitory factors and neovascularization inhibitors useful in preventing and treating various diseases in association with neovascularization. These neovascularization inhibitors contain as the active ingredient polypeptides with the following definition (a) or (b): (a) a polypeptide having an amino acid sequence of PyrGlu32-Val478 in HGF (hepatocyte growth factor); or (b) a polypeptide having an amino acid sequence derived from the amino acid sequence as defined in (a) by deletion, substitution or addition of one or several amino acids and having an antagonism to the effect of HGF via c-Met-HGF receptor.
Claims7
A method of inhibiting neovascularization induced by stimulation with bFGF or VEGF which comprises administering to a subject in need of such treatment a neovascularization inhibitor composition comprising the following polypeptide (a) or (b) and a pharmaceutically acceptable carrier:
- (a) a polypeptide having the amino acid sequence of SEQ ID NO:1;
- or
- (b) a polypeptide having the amino acid sequence of SEQ ID NO:2,
- wherein polypeptide (a) or (b) inhibits neovascularization induced by stimulation with bFGF or VEGF.
Dependencies are inferred from the claim text.