Catecholamine regulated protein
OwnerJoseph Gabriele, Ram Mishra +1inventors
InventorsJoseph Gabriele, Ram Mishra, Zdenek Pristupa
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Abstract
A novel family of mammalian catecholamine proteins is identified. These proteins are useful in methods of diagnosing neurological diseases, including schizophrenia and bipolar disease, as well as cardiovascular disease. This family of CRP40 proteins are also useful to treat neurological diseases.
Claims15
A human CRP40 protein comprising an amino acid sequence as defined in SEQ ID NO:
- 8, and functionally equivalent variants thereof exhibiting at least about 90% sequence homology, wherein the protein is not mortalin-2.
(canceled)
A method of treating a neurological disease in a mammal comprising administering to the mammal a therapeutically effective amount of at least one of a CRP40 protein comprising an amino acid sequence as set out in SEQ ID NO:8, mortalin-2 or a functionally equivalent variant of CRP40 or mortalin-2, in combination with a pharmaceutically effective carrier.
7-12. (canceled)
An article of manufacture comprising a composition and packaging, said composition comprising at least one compound selected from the group of CRP40, mortalin-2 and a functionally equivalent fragment of either of CRP40 or mortalin-2, in combination with a pharmaceutically acceptable carrier, and said packaging being labeled to indicate that the composition is effective to treat neurological disease.
(canceled)
Dependencies are inferred from the claim text.