Recombinant proteins containing shiga-like toxin and vascular endothelial growth factor fragments
AssigneeSibTech, Inc.
InventorsMarina V. Backer, Joseph M. Backer
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Abstract
The present invention is directed to an isolated polypeptide including: (1) the A subunit of Shiga-like bacterial toxin, wherein said subunit has the nucleic acid sequence of SEQ ID NO:9; and (2) human vascular endothelial growth factor wherein the growth factor has the nucleic acid sequence of SEQ ID NO:10; wherein the isolated polypeptide possesses ribosome inactivating activity. The present invention is also directed to compositions for inhibiting endothelial cell growth in a patient.
Claims8
An isolated polypeptide comprising:
- (1) the A subunit of Shiga-like bacterial toxin, wherein said subunit has the nucleic acid sequence of SEQ ID NO:9;
- and
- (2) human vascular endothelial growth factor, wherein said growth factor has the nucleic acid sequence of SEQ ID NO:10;
- wherein said isolated polypeptide possesses ribosome inactivating activity.
A composition for inhibiting endothelial cell growth in a patient, comprising:
- (A) a fusion protein comprising the A subunit of Shiga-like bacterial toxin;
- and human vascular endothelial growth factor, said fusion protein possessing ribosome inactivating activity;
- and
- (B) a pharmaceutically acceptable carrier;
- wherein said A subunit of said Shiga-like bacterial toxin, is encoded by the nucleic acid sequence of SEQ ID NO:9, and wherein said human vascular endothelial growth factor is encoded by the nucleic acid sequence of SEQ ID NO:11.
A fusion protein encoded by a nucleic acid sequence comprising SEQ ID NO:9 and SEQ ID NO:11.
A fusion protein encoded by a nucleic acid having the nucleic acid sequence of SEQ ID NO:11.
Dependencies are inferred from the claim text.