Methods of using cgrp for cardiovascular and renal indications
OwnerJeffery L. Southard, George Lee Southardinventors
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Abstract
The present invention provides methods of treating and preventing mortality associated with heart failure and renal insufficiency in a Stage B, C, or D heart failure patient, and for improving quality of life by providing improved methods of administering a therapeutically effective amount CGRP. One method comprise administering between about 50 and about 500 ng/min of CGRP for a time between 30 minutes and 8 hours per day for as many days as needed to provide symptomatic relief, prevent exacerbation of symptoms, and/or prevent and/or delay progression of the disease state of heart failure in said patient. The therapies can be administered on an outpatient or inpatient basis.
Claims22
A method of treating heart failure and/or renal failure in a patient, comprising administering CGRP to said patient at a rate between about 50 and 500 ng/min for a time between 30 minutes and 8 hours per day as needed to provide symptomatic relief, prevent exacerbation of symptoms, and/or prevent and/or delay progression of the disease state of heart failure in said patient.
A method of treating heart failure in a patient, comprising administering CGRP to said patient at a rate between about 500 and 600 ng/min for up to 8 hours per day for at least three consecutive days or several times per week as needed to provide symptomatic relief, prevent exacerbation of symptoms, and/or prevent and/or delay progression of the disease state of heart failure in said patient.
A method of treating heart failure and/or renal failure in a patent, comprising administering CGRP to a heart failure patient as an initial or maintenance therapy at a rate between 0.8 to 10 ng/kg/min two or more times per day as needed to provide symptomatic relief, prevent exacerbation of symptoms, and/or prevent and/or delay progression of the disease state of heart failure in said patient.
A method of preventing or reducing the risk of occurrence of myocardial infarction, comprising administering to a human at risk of having a myocardial infarction a CGRP formulation in an amount effective to prevent or reduce the risk of said myocardial infarction.
A method of counteracting ischemia in a patient, wherein said ischemia is due to a myocardial infarction, said method comprising administering CGRP to said patient as an initial or maintenance therapy, alone or in conjunction with other interventional therapies, at a rate between 0.8 to 16 ng/kg/min for up to 24 hours per day as needed to provide cardio protection, reduction in infarction size, reduction in reperfusion injury, symptomatic relief, and/or prevent exacerbation of symptoms.
Dependencies are inferred from the claim text.