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US 2009/0023642 A1Published application
Isolation, Purification, and Structure Elucidation of the Antiproliferative Compound Coibamide A
OwnerKerry Leigh McPhail, Rebecca Ann Medina +3inventors
InventorsKerry Leigh McPhail, Rebecca Ann Medina, William Henry Gerwick, Douglas Eugene Goerger, Todd Leo Capeon
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Abstract
Novel antiproliferative compounds, compositions comprising the same, and methods of use thereof are disclosed.
Claims9
A compound of formula I or a pharmaceutically acceptable salt thereof, wherein:
- wherein:
- R1=Me, H
- R2=Me, H
- R3=L/D N,N-dimethylvaline, L/D valine, L/D leucine, L/D isoleucine, L/D allo-isoleucine
- R4═O, NH, S, NMe
- R5=L/D 2-hydroxyisovaleric acid, L/D valine, L/D leucine, L/D isoleucine, L/D allo-isoleucine
- R6═H, Me
- R7=L/D serine, L/D O-methylserine
- R8═H, Me
- R9=L/D leucine, L/D valine, L/D isoleucine, L/D allo-isoleucine
- R10=Me, H
- R11═H, Me, CH3CH2—, CH3CH2CH2—
- R12═O, N, S
- R13=L/D alanine
- R14═H, Me
- R15=L/D tyrosine, L/D O-methyl tyrosine, L/D phenylalanine
- R16═H, Me
- R17=L/D leucine, L/D valine, L/D isoleucine, L/D allo-isoleucine
- R18═H, Me
- R19=L/D alanine
- R20═H, Me
- R21=L/D isoleucine, L/D allo-isoleucine, L/D leucine, L/D valine
- R22═H, Me
- R23=L/D serine, L/D O-methyl-serine
- R24═H, Me,
- wherein R3, R5, R7, R9, R13, R15, R17, R19, R21, R23 are the amino acid side chains of the listed amino acids.
23 more elements
Dependencies are inferred from the claim text.