Methods for detecting and treating interstitial cystitis
OwnerC. Lowell Parsonsinventor
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Abstract
The invention provides a method for diagnosing and inhibiting conditions associated with reduced amounts of THP and/or reduced amounts of total carbohydrate content in the THP, such as Interstitial Cystitis and its symptoms, and damaged mucin layers in a subject by administering an effective amount of a Tamm-Horsfall protein to the subject. The invention also provides a method for diagnosing Interstitial Cystitis in a subject by quantitatively determining in a sample, the level of THP, the amount of sialylation of Tamm-Horsfall protein and/or the total carbohydrate content in THP. A decrease in the amounts of THP, sialylation of Tamm-Horsfall protein and/or carbohydrate content in THP is indicative of Interstitial Cystitis.
Claims40
A method for inhibiting Interstitial Cystitis and its symptoms in a subject comprising administering an effective amount of a Tamm-Horsfall protein to the subject, so as to inhibit Interstitial Cystitis and its symptoms in the subject.
A method for increasing the levels of Tamm-Horsfall protein in a subject comprising administering to the subject an effective amount to Tamm-Horsfall protein, thereby increasing the levels of Tamm-Horsfall protein.
A method for diagnosing Interstitial Cystitis in a subject comprising quantitatively determining in the urine from the subject, the levels of Tamm-Horsfall protein and comparing the amount of Tamm-Horsfall protein so determined to the amount in a sample from a normal subject, the decrease in the amount of Tamm-Horsfall protein being indicative of Interstitial Cystitis.
A method for monitoring the course of Interstitial Cystitis in a subject which comprises quantitatively determining in a first sample of a urine from the subject the levels of Tamm-Horsfall protein and comparing the amount so determined with the amount present in a second sample from the subject, such samples being taken at different points in time, a difference in the levels of Tamm-Horsfall protein determined being indicative of the course of Interstitial Cystitis.
A method for screening for agents that modulate production of Tamm-Horsfall protein comprising:
- a) contacting Tamm-Horsfall genes in Tamm-Horsfall positive cells with a molecule of interest;
- and
- b) determining whether the contact results in increased Tamm-Horsfall production, increased Tamm-Horsfall production being indicative that the molecule modulates production of Tamm-Horsfall genes.
A method for screening for agents that modulate production of Tamm-Horsfall protein comprising:
- a) contacting Tamm-Horsfall protein in Tamm-Horsfall positive cells with a molecule of interest;
- and
- b) determining whether the contact results in increased Tamm-Horsfall production, increased Tamm-Horsfall production being indicative that the molecule modulates production of Tamm-Horsfall protein.
A method for screening for agents that modulate sialylation of Tamm-Horsfall protein comprising:
- a) contacting Tamm-Horsfall protein in Tamm-Horsfall positive cells with a molecule of interest;
- and
- b) determining whether the contact results in increased sialylation of Tamm-Horsfall protein, increased sialylation of Tamm-Horsfall protein being indicative of modulation of sialylation of Tamm-Horsfall protein.
A pharmaceutical composition comprising Tamm Horsfall protein and a pharmaceutically acceptable carrier.
A method for diagnosing Interstitial Cystitis in a subject comprising quantitatively determining in the urine from the subject, the amount of sialylation of Tamm-Horsfall protein and comparing the amount of sialylation of Tamm-Horsfall protein so determined to the amount in a sample from a normal subject, the decrease in the amount of sialylation of Tamm-Horsfall protein being indicative of Interstitial Cystitis.
A method for monitoring the course of Interstitial Cystitis in a subject which comprises quantitatively determining in a first sample of a urine from the subject the amount of sialylation of Tamm-Horsfall protein and comparing the amount so determined with the amount present in a second sample from the subject, such samples being taken at different points in time, a difference in the levels of sialylation of Tamm-Horsfall protein determined being indicative of the course of Interstitial Cystitis.
A method for diagnosing Interstitial Cystitis in a subject comprising quantitatively determining in the urine from the subject, the total amount of carbohydrates in Tamm-Horsfall protein and comparing the amount of carbohydrates in Tamm-Horsfall protein so determined to the amount in a sample from a normal subject, a decrease in the total amount of carbohydrates in Tamm-Horsfall protein being indicative of Interstitial Cystitis.
A method for monitoring the course of Interstitial Cystitis in a subject which comprises quantitatively determining in a first sample of a urine from the subject the total amount of carbohydrates in Tamm-Horsfall protein and comparing the amount so determined with the amount present in a second sample from the subject, such samples being taken at different points in time, a difference in the total amount of carbohydrates in Tamm-Horsfall protein determined being indicative of the course of Interstitial Cystitis.
Dependencies are inferred from the claim text.