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US 2009/0023635 A1Published application
Factor VII or VIIa - Like Molecules
AssigneeMaxygen Holdings Ltd.
InventorsAnders Hjelholt Pedersen, Kim Vilbour Andersen, Claus Bornaes
Life of this patent
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Abstract
Conjugates of Factor VII (FVII) and Factor VIIa (FVIIA) are provided, as are methods for preparing them. Methods for producing novel polypeptides contributing to the production of such conjugates are provided. Methods of treatment by administering a FVII or FVIIa conjugate are provided.
Claims19
1-67. (canceled)
A conjugate comprising:
- a polypeptide comprising an amino acid sequence which (a) differs from the hFVII or hFVIIa sequence SEQ ID NO:1 in 1-15 amino acid residues and (b) comprises an introduced in vivo N-glycosylation site relative to SEQ ID NO:1, wherein the introduced in vivo N-glycosylation site comprises the substitution K143N;
- and
- a sugar moiety covalently attached to the introduced in vivo N-glycosylation site.
A method for increasing blood clot formation in a mammal with a disease or condition in which increased clot formation is desirable, comprising administering to the mammal an amount of the conjugate of claim 1 effective to increase blood clot formation.
Dependencies are inferred from the claim text.