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US 2009/0023634 A1Published application
Regulation of mineral and skeletal metabolism
AssigneeAcologix, Inc.
InventorsThomas Haberberger, David Rosen, Yoshinari Kumagai
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Abstract
A method is disclosed whereby levels of calcium, phosphate and parathyroid hormone are measured in a patient. The patient is treated with a formulation comprising a compound having phosphotonin activity and thereafter measurements are made again. Dosing of the formulation is adjusted based on measurements with measuring, administering and adjusting dosing continually repeated as needed.
Claims19
-16. (canceled)
A method of treating a subject, comprising:
- diagnosing the subject as having hyperparathyroidism and high calcium-phosphorus;
- administering to a subject a therapeutically effective amount of a formulation comprised of a carrier and a molecule chosen from amino acid sequences indicated by the SEQ ID No. 2, 3, 5, 6, 8-13 and a biologically active fragment thereof comprising at least 51 amino acids in length and has phosphotonin activity;
- and
- reducing circulating levels of calcium, phosphate, and parathyroid hormone simultaneously in the subject.
1 more element
-42. (canceled)
The method as claimed in claim 18, further comprising:
- (a) measuring levels of parathyroid hormone (PTH), phosphate (PO4) and calcium (Ca) in a patient;
- (b) administering to the patient a dose of formulation comprising a carrier and a peptide having phosphotonin activity;
- and
- (c) re-measuring levels of (PTH), (PO4) and (Ca) in the patient to determine levels after administering the peptide with phosphotonin activity. 52. The method of claim 51, further comprising:
- (d) adjusting the dose in (b) based on the levels of (PTH), (PO4) and (Ca) determined in (c).
2 more elements
The method of claim 52, further comprising:
- (e) repeating any of (a)-(d).
Dependencies are inferred from the claim text.