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US 2009/0023633 A1Published application
Regulation of mineral and skeletal metabolism
AssigneeAcologix, Inc.
InventorsThomas Haberberger, David Rosen, Yoshinari Kumagai
Life of this patent
Estimating the term…
Abstract
A method is disclosed whereby levels of calcium, phosphate and parathyroid hormone are measured in a patient. The patient is treated with a formulation comprising a compound having phosphotonin activity and thereafter measurements are made again. Dosing of the formulation is adjusted based on measurements with measuring, administering and adjusting dosing continually repeated as needed.
Claims22
-11. (canceled)
A method of treating a subject, comprising:
- diagnosing the patient as suffering from hyperparathyroidism and hyperphosphatemia simultaneously;
- and
- administering to a subject a therapeutically effective amount of a formulation comprised of a carrier and a molecule chosen from amino acid sequences indicated by the SEQ ID No. 2, 3, 5, 6, 8-13 and a biologically active fragment thereof comprising at least 51 amino acids in length and has phosphotonin activity.
A method of treating a subject, comprising:
- administering to a subject a therapeutically effective amount of a formulation comprised of a carrier and a molecule chosen from amino acid sequences indicated by the SEQ ID No. 2, 3, 5, 6, 8-13 and a biologically active fragment thereof comprising at least 51 amino acids in length and has phosphotonin activity;
- and
- reducing calcium-phosphorus product in the circulation of the subject who suffers from hypercalcemia, hyperphosphatemia, or combination thereof.
-42. (canceled)
Dependencies are inferred from the claim text.