Hemoglobin-haptoglobin complexes
AssigneeHemosol Inc.
InventorsJ. Gordon Adamson, Jolanta M. Wodzinska, M. S. Moore
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Abstract
Construct-complexes of a hemoglobin, a hepatocyte modifying substance bound to the hemoglobin, and a haptoglobin bound to the hemoglobin, are provided, for administration to mammalian patients. The construct-complex may be formed ex vivo, or a hemoglobin-hepatocyte modifying substance combination may be administered to the patient so that haptoglobin in the mammalian body bonds thereto to form the construct-complex in vivo. Disorders of the liver may be diagnosed and treated using construct-complexes described herein.
Claims30
A hemoglobin construct-complex comprising a hemoglobin and a hepatocyte modifying substance bound thereto, said construct-complex being capable of binding to haptoglobin in vivo in a mammalian patient to effect delivery of the hepatocyte modifying substance to hepatocytes of the patient.
A hemoglobin construct-complex comprising a hemoglobin, a hepatocyte modifying substance bound to the hemoglobin, and a haptoglobin bound to the hemoglogin.
A process for treating or diagnosing hepatocytic disorders in a mammalian patient which comprises administering to the patient an effective amount of a construct-complex.
Dependencies are inferred from the claim text.