Compositions comprising polycation-complexed protein crystals and methods of treatment using them
AssigneeAltus Pharmaceuticals Inc.
InventorsSusan Yun Qu, Shubhang Mishra, Benjamin Paul Simeone, Sujit Kumar Basu
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Abstract
The present invention relates to compositions comprising polycation-complexed protein crystals and hyaluronic acid. Advantageously, the compositions of this invention are stable, long-acting and avoid local reactions at the injection site. Compositions according to this invention include sustained-release human growth hormone compositions. Such compositions are useful for treating a subject having a disorder associated with human growth hormone deficiency or that is ameliorated by human growth hormone therapy.
Claims24
A composition comprising a polycation-complexed protein crystal and hyaluronic acid.
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A method for reducing the surface charge on a polycation-complexed protein crystal, comprising the step of adding hyaluronic acid to said polycation-complexed protein crystal.
A method for preparing a sustained release composition of a protein comprising the steps of:
- (a) forming a protein crystal;
- (b) complexing the protein crystal with a polycation to form a polycation-complexed protein crystal;
- and
- (c) formulating the polycation-complexed protein crystal with hyaluronic acid.
A method for preparing a sustained release composition of a protein comprising the steps of:
- (a) complexing a protein crystal with a polycation to form a polycation-complexed protein crystal;
- and
- (b) formulating the polycation-complexed protein crystal with hyaluronic acid.
A method for preparing a sustained- release composition of a protein comprising the steps of:
- (a) co-crystallizing a protein with a polycation to form a co-crystal;
- and
- (b) formulating the co-crystal with hyaluronic acid.
A method for reducing or preventing an injection site reaction in a mammal caused by an administration of a polycation-complexed protein crystal comprising the step of formulating the polycation-complexed protein crystal with hyaluronic acid and injecting said formulation into said mammal.
Dependencies are inferred from the claim text.