Beaded and Cross-Linked Poly(Aminoalkylene)Matrix and Uses Thereof
AssigneeVersamatrix A/S
InventorsPatrik Gavelin, Nicola Pehr-Rehnberg, Ib Johannsen
Life of this patent
Estimating the term…
Abstract
The present invention relates to the synthesis of a beaded and cross-linked, high loading capacity polymer for solid phase synthesis, purification of reaction mixtures, chromatographic separation procedures, and the like. The invention can thus be used for the isolation of molecular entities having an affinity for the polymer beads or a chemical entity attached thereto. The beaded polymer matrix can be formed by cross-linking an optionally substituted poly(aminoalkylene), under inverse suspension or inverse emulsion polymerisation conditions, with a cross-linking unit of functionality ≧2.
Claims24
A beaded polymer matrix, formed by cross-linking of optionally substituted poly(aminoalkylene), under inverse suspension or inverse emulsion polymerisation conditions, of Formula I
- wherein A is a cross-linking unit of functionality ≧2,
- with the proviso that when poly(aminoalkylene) is poly(allylamine) then at least 1% of all nitrogens are substituted, and with the further proviso that when poly(aminoalkylene) is poly(vinylamine) then A is not (a) a polymethylene of the formula (CH2)r wherein r is an integer from 2 to 10, or (b) an optionally substituted xylylene, or (c) a diimine linked by a polymethylene of the formula (CH2)s wherein s is an integer from 2 to 5, or (d) an optionally substituted xylylene, or (e) CH2CHOHCH2 or CH2CHCH2OH.
(canceled)
(canceled)
A beaded cross-linked poly(aminoalkylene) matrix obtained by radical polymerization of a molecule of Formula IV having a radical reactive group R4R′″C═CR″—CY
- wherein
- n is a number from 0 to 10;
- m is a number from 3 to 15000;
- o is number 0 or 1;
- p is a number >0 and <m;
- Y is a heteroatom or a pair of hydrogens;
- and
- R″, R′″, R4, and R5 are independently selected from the group consisting of hydrogen, optionally substituted saturated or unsaturated alkyl, optionally substituted saturated or unsaturated acyl, and optionally substituted aryl groups.
Use of a granulated or beaded cross-linked polymer matrix comprising a plurality of functional groups selected from the group consisting of optionally substituted primary amines and secondary amines for scavenging undesirable chemical compounds from a composition comprising a mixture of chemical entities, as support for immobilised.
Dependencies are inferred from the claim text.