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AssigneeFisher Bioimage APS
InventorsOle Thastrup, Sara Petersen Bjorn, Soren Tullin, Kasper Almholt, Kurt Scudder
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A method for screening a library of compounds to detect a biologically active compound that modulates intracellular translocation of a subunit of a component of an intracellular pathway affecting intracellular processes includes: culturing one or more cells containing a nucleotide sequence coding for a hybrid polypeptide comprising a luminophore linked to the subunit of the component; introducing a compound of the library of compounds into the cell culture; screening the compound to determine whether the compound modulates the intracellular translocation of the subunit of the component; measuring light emitted from the luminophore to determine a first distribution; measuring light emitted from the luminophore to determine a second distribution; computing a variation between the first distribution and the second distribution by processing the measured light, any variation is indicative that the compound is biologically active. The method is also performed with a library of compounds.
A method for screening a library of compounds to detect a biologically active compound that modulates intracellular translocation of at least a subunit of a component of an intracellular pathway affecting intracellular processes, the method comprising:
A method for screening a library of compounds to detect a biologically active compound that modulates intracellular translocation of at least a subunit of a component of an intracellular pathway affecting intracellular processes, the method comprising:
A method for screening a library of compounds to detect a biologically active compound that modulates intracellular translocation of at least a subunit of a component of an intracellular pathway affecting intracellular processes, the method comprising:
Dependencies are inferred from the claim text.