Temperature-Adjusted Analyte Determination For Biosensor System
AssigneeBayer HealthCare LLC
InventorsHuan-Ping WU, Christine D. Nelson
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Abstract
A biosensor system determines analyte concentration from an output signal generated by an oxidation/reduction reaction of the analyte. The biosensor system adjusts a correlation for determining analyte concentrations from output signals at one temperature to determining analyte concentrations from output signals at other temperatures. The temperature-adjusted correlation between analyte concentrations and output signals at a reference temperature may be used to determine analyte concentrations from output signals at a sample temperature.
Claims32
A method for determining an analyte concentration in a sample of a biological fluid, comprising:
- determining a sample temperature;
- generating an output signal in response to a redox reaction of an analyte in the sample;
- adjusting a correlation between analyte concentrations and output signals at a reference temperature in response to temperature;
- and
- determining the analyte concentration from the temperature-adjusted correlation and the output signals at the sample temperature.
A method for adjusting a correlation between analyte concentrations and output signals at a reference temperature in response to temperature, comprising:
- determining the correlations between analyte concentrations and output signals for a reference temperature and at least one other temperature;
- developing normalized temperature functions of slope and intercept for the correlation of the reference temperature;
- and
- adjusting the correlation of the reference temperature in response to the normalized temperature functions of slope and intercept.
A biosensor for determining an analyte concentration in a biological fluid, comprising:
- a measuring device having a processor connected to a sensor interface and a temperature sensor;
- a sensor strip having a sample interface on a base, where the sample interface is adjacent to a reservoir formed by the base;
- and
- where the processor adjusts a correlation between analyte concentrations and output signals at a reference temperature in response to a sample temperature from the temperature sensor, and
- where the processor determines an analyte concentration from the temperature-adjusted correlation in response to an output signal from the sample interface.
Dependencies are inferred from the claim text.