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AssigneeExigon A/S
InventorsGregor Obernosterer, Nina Stahlberg, Soren Moller, Soren M. Echwald, Peter Mouritzen, Peter S. Nielsen, Mikkel Norholm, Kim Bundvig Barken
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The invention relates to ribonucleic acids and oligonucleotide probes useful for detection and analysis of microRNA precursors and their targets. The invention furthermore relates to oligonucleotide probes for detection and analysis of other non-coding RNAs, mRNAs, mRNA splice variants, allelic variants of single transcripts, mutations, deletions, or duplications of particular exons in transcripts, e.g., alterations associated with human disease, such as cancer.
An oligonucleotide probe that hybridizes to a miRNA precursor molecule, said probe comprising a plurality of nucleotide analogue monomers, wherein at least part of said probe hybridizes to a portion of said precursor not present in the corresponding mature miRNA.
Dependencies are inferred from the claim text.