Devices, systems and methods for isometric and isotonic contraction of blood vessels using an isovolumetric myograph
AssigneeDTherapeutics, LLC
InventorsGhassan S. Kassab, Xiao Lu
Life of this patent
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Abstract
The present invention discloses devices, systems and methods for the isovolumic measurement of vasoactivity in a blood vessel (3). The length and volume of the blood vessel (3) are maintained constant while a chemical or pressure is exposed to the blood vessel (3). The reaction of the blood vessel (3) to the chemical or physical stimuli is measured by internal lumen pressure changes.
Claims27
A device for determining the vasoactivity of a first blood vessel, the device comprising:
- a pair of conduits positioned at either end of a blood vessel having a lumen, wherein each conduit forms a fluid seal with the lumen of the blood vessel;
- a pair of retaining walls that retain the blood vessel in a predetermined length;
- a first pressure transducer in communication with at least one of the conduits;
- and
- wherein any vasoactivity of the blood vessel is influenced by pressure fluctuations in the lumen of the blood vessel as measured by the first pressure transducer while the blood vessel is maintained in the predetermined length by the pair of retaining walls.
(canceled)
A system for determining the vasoactivity of a first blood vessel in reaction to a chemical, the system comprising:
- a blood vessel having a lumen, the blood vessel used to determine the vasoactivity of a blood vessel in response to a chemical;
- wherein the lumen of the blood vessel is closed to flow conditions such that the blood vessel is maintained at constant volume;
- a retaining device having retaining walls that retains the blood vessel in a predetermined length;
- a chemical used to test the vasoactivity of the blood vessel;
- and
- wherein any vasoactivity of the blood vessel in response to the chemical is measured in an isovolumic and isometric state.
A method for measuring the vasoactivity of a blood vessel having a lumen in response to a chemical, the method comprising:
- maintaining the blood vessel at a constant length;
- maintaining the blood vessel at a constant internal volume;
- and
- measuring pressure changes inside the lumen of the blood vessel after exposure of the blood vessel to the chemical.
(canceled)
Dependencies are inferred from the claim text.