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AssigneeInje University Industry-Academic Cooperation Foundation
InventorsWon Sun Park, Na Ri Kim, Jin Han
Estimating the term…
The present invention relates to a method of screening placental proteins responsible for pathophysiology of preeclampsia, and a marker for early diagnosis and prediction of preeclampsia. In accordance with one aspect of the present invention, there is provided a method of screening placental proteins responsible for pathophysiology of preeclampsia by 2D E-proteomics analysis, comprising: isolating placental proteins from a placental tissue; separating the isolated proteins two-dimensionally through 2D electrophoresis; and comparing and analyzing the separated proteins based on scanned gel images and differences in the images between normal placental proteins and preeclamptic placental proteins, wherein the comparison and analysis of the placental proteins based on the scanned gel images and differences in the images are accomplished by selecting proteins with differences of 140% or more between two placentas.
A method of screening placental proteins responsible for pathophysiology of preeclampsia by 2D E-proteomics analysis, comprising:
A marker for early diagnosis and prediction of preeclampsia, comprising one or more proteins selected from the protein group consisting of chaperonin, ER-60 protease, isocitrate dehydrogenase 1, aldehyde reductase 1, fidaresta chain B bonded to human aldose reductase, voltage-dependent anion channel 1, nuclear chloride channel, cathepsin D chain H, phosphoglycerate mutase 1, endoplasmic reticulum protein, PSMA2 protein, glutathione S-transferase, Ig heavy chain v region, smooth muscle myosin alkali light chain, and fatty acid binding protein.
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