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US 2009/0023160 A1Published application
Antibodies specific for CYP1B1
AssigneeThe University Court of the University of Aberdeen
InventorsWilliam Melvin, Graeme Ian Murray
Life of this patent
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Abstract
Antibodies that can specially bind to cytochrome P450 CYP1B1 and methods of making them are disclosed, in particular antibodies that bind to amino acid sequence VNQWSVNHDPVKWPN or PExFDPARFLDKDGy, where x is D or N and y is L or F, or an antigenic fragment thereof. The antibodies can be used in the diagnosis or treatment of cancers linked to enhanced CYP1B1 expression, including breast cancer, prostate cancer, colorectal cancer, liver cancer and ovarian cancer.
Claims16
1-25. (canceled)
An assay method for detecting cancer cells present in a sample from a patient, the method comprising:
- contacting a tissue sample from the patient with an antibody which is capable of specifically binding to cytochrome P450 CYP1B1, wherein the antibody recognizes an epitope in the cytochrome P450 CYP1B1 protein included within the amino acid sequence VNQWSVNHDPVKWPN (SEQ ID NO:1) or PExFDPARFLDKDGy, where x is D or N and y is L or F (SEQ ID NOs:
- 2 to 5);
- and,
- detecting binding of the antibody to CYP1B1 protein present in the sample as an indication of the presence of cancer cells in the tissue sample.
1 more element
Dependencies are inferred from the claim text.