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US 2009/0023153 A1Published application
Targeted modification of chromatin structure
AssigneeSangamo BioSciences, Inc.
InventorsAlan P. Wolffe, Trevor Collingwood
Life of this patent
Estimating the term…
Abstract
Methods and compositions for targeted modification of chromatin structure, within a region of interest in cellular chromatin, are provided. Such methods and compositions are useful for facilitating processes such as, for example, transcription and recombination, that require access of exogenous molecules to chromosomal DNA sequences.
Claims7
A method of screening for a compound that modulates the activity of a chromatin modifying enzyme, the method comprising the steps of:
- (a) contacting a cell with the compound, wherein the cell comprises a fusion protein comprising a zinc finger protein and a functional chromatin modifying enzyme or fragment thereof and wherein the ZFP binds to a gene within the cell;
- and
- (b) determining the level of expression of the gene.
Dependencies are inferred from the claim text.