Transcription factor MHC class II genes, substances capable of inhibiting this transcription factor and medical uses of these substances
OwnerKrysztof Masternak, Walter Reith +1inventors
InventorsKrysztof Masternak, Walter Reith, Bernard Mach
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Abstract
The present invention relates to a transcription factor of MHC class II genes and its derivatives, inhibitors down-regulating the expression of MHC class II molecules, process to identify these inhibitors and medical uses of these inhibitors.
Claims10
A method of restoring expression of at least one MHC-II molecule in a cell from an MHC-II deficiency patient in complementation group B, said method comprising contacting said cell with an isolated polypeptide comprising the amino acid sequence of SEQ ID NO:
- 11.
A method of restoring expression of at least one MHC-II molecule in a cell from an MHC-II deficiency patient in complementation group B, said method comprising contacting said cell with an isolated nucleic acid comprising the nucleotide sequence of SEQ ID NO:
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Dependencies are inferred from the claim text.