Diagnostics and therapeutics for osteoporosis
OwnerKenneth Kornman, Paul Martha +4inventors
InventorsKenneth Kornman, Paul Martha, Gordon W. Duff, Simon Van Dijk, Nazneen Aziz, Hwa-Ying Wang
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Abstract
Diagnostics and therapeutics for osteoporosis, which are bases upon the identification of a subjects IL-1 haplotype and genotype pattern are described.
Claims18
A method for detecting whether a subject is predisposed to developing osteoporosis or complication thereof, comprising detecting allele 2 of the −511 marker of IL-1B, wherein the presence of allele 2 of the −511 marker of IL-1B indicates that the subject is predisposed to the development of osteoporosis or complication thereof.
A method for detecting whether a subject is predisposed to developing osteoporosis or complication thereof, comprising detecting allele 2 of the +2018 marker of IL-1RN, wherein the presence of allele 2 of the +2018 marker of IL-1RN indicates that the subject is predisposed to the development of osteoporosis or complication thereof.
A method for detecting whether a subject is predisposed to developing osteoporosis or complication thereof, comprising detecting allele 2 of the −511 marker of IL-1B and allele 2 of the +2018 marker of IL-1RN, wherein the presence of both alleles indicates that the subject is predisposed to the development of osteoporosis or complication thereof.
A method for detecting whether a subject is predisposed to developing osteoporosis or complication thereof, comprising detecting allele 2 of +4845 marker of IL-1A, wherein the presence of allele 2 of +4845 marker of IL-1A indicates that the subject is predisposed to the development of osteoporosis or complication thereof.
A method for detecting whether a subject is predisposed to developing osteoporosis or complication thereof, comprising detecting allele 2 of −3737 marker of IL-1B, wherein the presence of allele 2 of −3737 marker of IL-1B indicates that the subject is predisposed to the development of osteoporosis or complication thereof.
A method for detecting whether a subject has a reduced risk for developing osteoporosis or complication thereof, comprising detecting allele 2 of +3954 marker of IL-1B, wherein the presence of allele 2 of +3954 marker of IL-1B indicates that the subject has a reduced risk for developing of osteoporosis or complication thereof.
Dependencies are inferred from the claim text.