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US 2009/0023133 A1Published application
Genomic markers of hepatitis b virus associated with hepatocellular carcinoma
AssigneesThe Chinese University of Hong Kong, Hospital Authority
InventorsJao Yiu Joseph SUNG, Lik Yuen Chan, Kwok Wing Stephen Tsui, Kwong Sak Leung, Shu Kam Tony Mok, Angeline Bartholomeusz, Wai Yee Nancy Leung, Kin Hong Lee
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Abstract
The present invention provides methods of predicting a pre-disposition of HBV-infected individuals to develop hepatacellular carcinoma (HCC).
Claims19
A method of determining a pre-disposition of an individual infected with hepatitis B virus (HBV) to develop hepatocellular carcinoma (HCC), the method comprising:
- a) determining a nucleotide in the genome of HBV isolated from the individual at least the position corresponding to nucleotide 31 of SEQ ID NO:1;
- and
- b) determining the presence or absence of 31C in the HBV genome, wherein if the HBV genome has 31C, the individual has a predisposition to develop HCC.
A kit for detecting HBV isolates that are associated with the development hepatocellular carcinoma (HCC), comprising
- one or more probe which, when contacted to an HBV genome, selectively hybridizes to the genome if the genome comprises a C at a position corresponding to position 31 of SEQ ID NO:1.
A computer readable medium comprising,
- a) code for receiving information describing:
- nucleotides at positions corresponding to nucleotides 31 of SEQ ID NO:1;
- b) code for comparing the nucleotides received in a) to nucleotides associated with a pre-disposition to cause HCC;
- and
- c) code for providing a determination of the pre-disposition of the HBV to cause HCC,
- wherein nucleotides associated with a pre-disposition to cause HCC comprise:
- 31C.
4 more elements
Dependencies are inferred from the claim text.