Antimicrobial constructs
AssigneesAllvivo Vascular, Inc., The State of Oregon Acting by and through the State Board of Higher Ed. on Behalf of Oregon, State Univ.
InventorsJennifer A. Neff, Joseph McGuire, Pranav R. Joshi
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Abstract
The invention is based on the recognition that known antimicrobial compounds, such as nisin or other lantibiotics, can be made to form a long lasting antimicrobial surface coating by linking the peptide with a block polymer, such as PLURONIC® F108 or an end group activated polymer (EGAP) in a manner to form a flexible tether and/or entrap the peptide. The entrapped peptide provides antimicrobial action by early release from entrapment while the tethered peptide provides longer lasting antimicrobial protection. Antimicrobial gels and foams may be prepared using the antimicrobial peptide containing block copolymers.
Claims19
A block copolymer which has an antimicrobial component, wherein a quantity of the antimicrobial is covalently attached to the block copolymer and another quantity of the antimicrobial component is entrapped in the strands of the block copolymer.
A block copolymer that contains a quantity of an antimicrobial component, wherein the antimicrobial component is entrapped in the strands of the copolymer.
A composition of matter comprising particles of a block copolymer, said particles comprising an antimicrobial component that is attached to the block copolymer in a manner to form an antimicrobial surface, wherein a portion of the antimicrobial component is entrapped in the strands of the copolymer.
A method of forming an antimicrobial coating on a substrate, said method comprising the steps of:
- forming an coating comprising particles of a block polymer, the block copolymer comprising an antimicrobial component;
- and
- exposing said substrate to an atmosphere of the coated block polymer for a time to form a layer of the coating on the substrate.
A method of forming an antimicrobial coating on a substrate, said method comprising the steps of:
- exposing the substrate to a solution comprising a block polymer for a time sufficient to coat the substrate with the copolymer;
- and
- exposing the coated substrate into a solution containing an antimicrobial peptide such that a quantity of the antimicrobial component covalently attaches to the copolymer and a quantity becomes entrapped in the copolymer.
Dependencies are inferred from the claim text.