Coated Hyaluronic Acid Particles
AssigneeAllergan, Inc.
InventorsJulie A. Champion, Samir Mitragotri, Ahmet Tezel
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Abstract
The present invention generally relates to particles comprising hyaluronic acid, wherein the particles are coated or encapsulated with a coating. The coating preferably comprises a polymer, protein, polysaccharide, or combination thereof that decreases the rate of degradation of the hyaluronic acid once the particles are placed in an aqueous environment, such as inside mammalian skin. The compositions of the present invention comprising such coated hyaluronic acid are useful for soft tissue augmentation, and are particularly useful as dermal fillers.
Claims15
A composition for soft tissue augmentation, said composition comprising hyaluronic acid coated with a coating to form coated hyaluronic acid, the coating comprising a biodegradable polymer, nondegradable polymer, protein, polysaccharide, or a combination thereof, wherein the composition is suitable for subcutaneous injection in a mammal.
A composition comprising hyaluronic acid particles, wherein the hyaluronic acid particles are encapsulated in a polymer, protein, polysaccharide, or a combination thereof, to form encapsulated hyaluronic acid particles, and wherein the encapsulated hyaluronic acid particles are generally spherical in shape.
A dermal filler for skin augmentation comprising coated particles of hyaluronic acid, said coated particles of hyaluronic acid comprising a coating that decreases the rate of degradation of the hyaluronic acid in an aqueous environment.
A method for repairing or augmenting soft tissue in mammals comprising the steps of:
- selecting the mammalian soft tissue to be repaired or augmented and placing into the mammal's soft tissue an injectable, bioresorbable composition comprising hyaluronic acid particles coated in a polymer, protein, or polysaccharide.
Dependencies are inferred from the claim text.