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US 2009/0022805 A1Published application
Polypeptide microparticles having sustained release characteristics, methods and uses
OwnerJoram Slager, Michael D. New +4inventors
InventorsJoram Slager, Michael D. New, John V. Wall, Michael J. Burkstrand, Stephen J. Chudzik, Pamela J. Reed
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Abstract
The invention provides polypeptide microparticles having control release features, particular methods for the preparation of such microparticles, and drug delivery systems that include polypeptide microparticles.
Claims27
A microparticle comprising:
- (a) a core comprising predominantly polypeptide;
- and
- (b) a microparticle coating, the microparticle coating comprising a crosslinked polymeric matrix, wherein the polypeptide is capable of being released from the microparticle and wherein the microparticle coating is able to modulate release of the polypeptide from the microparticle.
A method for forming a microparticle comprising a core comprising
- predominantly polypeptide and a microparticle coating comprising a crosslinked polymeric matrix, the method comprising the steps of:
- (a) in a liquid composition, providing a core particle comprising predominantly polypeptide;
- (b) mixing the core particle with a first component comprising a first reactive group;
- (c) mixing the core particle with a second component comprising a polymer and a pendent a second reactive group;
- wherein either:
- (i) the first reactive group is reactive with the second reactive group, thereby forming the crosslinked polymeric matrix, or
- (ii) the first reactive group comprises a polymerization initiator group and the second reactive group comprises a polymerizable group, and the method additionally comprises (d) activating the initiator group to cause polymerization of the first component, thereby forming the crosslinked polymeric matrix, and
- wherein step (b) can be performed before, after, or at the same time as step (c).
5 more elements
A method for forming a microparticle comprising a core comprising
- predominantly polypeptide and a microparticle coating comprising a crosslinked polymeric matrix, the method comprising the steps of:
- providing a liquid composition comprising polypeptide, nucleating agent, and polymer comprising pendent reactive groups;
- (b) heating the composition to a temperature above room temperature;
- (c) adding a phase separation agent comprising an amphiphilic compound to the composition;
- (d) cooling the composition formed in step (c);
- (e) extracting at least a portion of the phase separation agent;
- and
- (f) activating the pendent reactive groups to crosslink the polymer to form the crosslinked polymeric matrix.
5 more elements
An elution control matrix for the controlled release of a polypeptide, comprising:
- a polymeric matrix and polypeptide microparticles within the polymeric matrix,
- wherein the polypeptide microparticles comprise predominantly polypeptide and a crosslinked polymeric component.
Dependencies are inferred from the claim text.