Systems, devices, and methods for iontophoretic delivery of compositions including liposome-encapsulated insulin
OwnerKentaro Kogure, Misuzu Watanabe +1inventors
InventorsKentaro Kogure, Misuzu Watanabe, Hideyoshi Harashima
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Abstract
Systems, devices, and methods for delivering one or more active ingredients to intradermal tissues, deep regions of pores, and intradermal tissues in the vicinity of pores. In some embodiments, a composition is provided including a plurality of liposomes including a cationic lipid, and an amphiphilic glycerophospholipid having a saturated fatty acid moiety and an unsaturated fatty acid moiety, and at least one insulin, insulin analog, or insulin derivative.
Claims31
A composition, comprising:
- a plurality of liposomes comprising:
- a cationic lipid, and
- an amphiphilic glycerophospholipid having a saturated fatty acid moiety and an unsaturated fatty acid moiety;
- and
- at least one insulin molecule;
- wherein the at least one insulin molecule is enclosed within a liposome;
- and
- wherein the composition is suitable for iontophoretic delivery of the at least one insulin molecule to a biological subject.
A method for treating or preventing a condition or a disease associated with increased blood glucose levels in a biological subject, comprising:
- iontophoretically administering to the biological subject in need of such treatment a therapeutically effective amount of a composition comprising a plurality of liposomes comprising a cationic lipid, an amphiphilic glycerophospholipid having a saturated fatty acid moiety and an unsaturated fatty acid moiety, and at least one insulin molecule, the at least one insulin molecule being carried by the plurality of liposomes, the cationic lipid present in a molar ratio of the cationic lipid to the amphiphilic glycerophospholipid of about 9:1 to about 1:9, and the liposome having a mean particle diameter of about 400 nm to about 1000 nm.
Dependencies are inferred from the claim text.