Phenytoin Formulations, and Uses Thereof in Wound Healing
AssigneeRoyal College of Surgeons In Ireland
InventorsJohn Kelly, Cormac Kennedy, Clare Meaney
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Abstract
A formulation of phenyloin suitable for topical application to a wound comprises a reservoir of phenyloin entrapped within a stabilising matrix, and an amount of dissolved phenyloin, wherein the dissolved phenyloin is in chemical equilibrium with the phenyloin entrapped within the stabilised matrix. The stabilised matrix may comprise a gel matrix, especially a gel matrix in which the polymer of the gel forms ion-pairs with the phenyloin. Also described are methods of treating a wound in diabetic and non-diabetic patients using a formulation according to the invention.
Claims21
A formulation of phenyloin suitable for topical application to a wound comprising a reservoir of phenyloin entrapped within a gel, and an amount of phenyloin dissolved in an aqueous component of the gel, wherein the dissolved phenyloin is in chemical equilibrium with the phenyloin entrapped within the gel, in which the gel is formed by a gelling agent suitable for forming an ion pair with the phenyloin, wherein the formation of ion-pairs between the gelling agent and the phenyloin molecules increases the stability of the reservoir of phenyloin, wherein the formulation has a pH of from 7 to 10, and wherein the gel comprises an acidic polymer.
Dependencies are inferred from the claim text.