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US 2009/0022775 A1Published application
Polymer backbone for producing artificial tissue
AssigneeBASF SE
InventorsSimon Champ, Matthias Maase, Sascha Deck
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Abstract
The invention relates to polymer scaffolds suitable for producing artificial tissues, in particular polysaccharide scaffolds, to processes for their preparation, to their use for producing artificial tissues, and to artificial tissues produced on the basis of such polymer scaffolds.
Claims26
A process for producing two- or three-dimensional scaffolds of biodegradable and biocompatible polymers which comprises the following steps:
- (i) solubilization of a biodegradable and biocompatible polymer in a chaotropic liquid;
- and
- (ii-a) substantially continuous extrusion of the solution obtained in step (i) into a liquid medium which is miscible with the chaotropic liquid but in which the polymer is substantially insoluble, by means of a needle, where the needle and the resulting scaffold move relative to one another during the extrusion;
- or
- (ii-b) extrusion of the solution obtained in the first step into a liquid medium which is miscible with the chaotropic liquid but in which the polymer is substantially insoluble, by means of a needle to form individual straight, curved or bent polymer strands, where the needle and the resulting polymer strand move relative to one another during the extrusion step, if appropriate isolation of the polymer strands from the liquid medium and linkage of the polymer strands to form a two- or three-dimensional scaffold.
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Dependencies are inferred from the claim text.