Chitosan Compositions
OwnerMats Anderssoninventor
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Abstract
This invention relates to an orthopaedic composition comprising porous chitosan particles suspended in a liquid medium wherein the liquid medium further comprises a biocompatible polymer. The invention also provides a process for preparing a solid or semi-solid orthopaedic material by drying the orthopaedic composition. The resulting solid or semi-solid orthopaedic material finds use as a bone-replacement material, a bone cement and a tissue scaffold. A process for preparing suitable porous chitosan particles for the present invention by incorporating a porogen capable of including crystallinity is also described.
Claims34
An orthopaedic composition comprising porous chitosan particles suspended in a liquid medium wherein the liquid medium further comprises a biocompatible polymer.
An orthopaedic composition as claimed in any preceding claim, wherein the particles contain at least 50% chitosan.
An orthopaedic composition as claimed in any preceding claim, wherein the particles contain 50 to 90% chitosan.
An orthopaedic composition as claimed in any preceding claim, wherein the liquid medium further comprises a plasticiser.
An orthopaedic composition as claimed in any preceding claim, wherein the biocompatible polymer is a polysaccharide or protein.
An orthopaedic composition as claimed in any preceding claim, wherein the biocompatible polymer is a charged polymer.
An orthopaedic composition as claimed in any preceding claim, wherein the biocompatible polymer is dissolved in the liquid medium.
An orthopaedic composition as claimed in any preceding claim, wherein the liquid medium is an aqueous medium.
A process for preparing a solid or semi-solid orthopaedic material comprising drying the orthopaedic composition as claimed in any preceding claim.
A process for preparing porous chitosan particles comprising:
- preparing a solution containing chitosan and a porogen capable of inducing crystallinity in to the chitosan, drying the solution to a solid residue, and milling the solid residue to generate the porous chitosan particles.
Dependencies are inferred from the claim text.