Continuous flow chamber device for separation, concentration, and/or purification of cells
OwnerMichael R. King, Jane Liesveld +1inventors
InventorsMichael R. King, Jane Liesveld, Kuldeepsinh Rana
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Abstract
The present invention relates to methods and apparatuses for neutralizing cancer cells. In particular, the invention relates to separating of cancer cell type from a mixture of different cell types based on the differential rolling property of cancer cell on a substrate coated with a first molecules that exhibits adhesive property with the particular cell type and neutralizing the cancer cell by a second molecule that is also coated on the substrate. This technology is adaptable for use in vivo, in vitro, or ex vivo tumor neutralization.
Claims28
A device for neutralizing cancer cells comprising a flow chamber, wherein a wall of the chamber contains
- an adhesive molecule that selectively interacts with the cancer cells,
- and a molecule that neutralizes the cancer cells.
A method for neutralizing cancer cells comprising the steps of
- providing a flow surface containing an adhesive molecule that selectively interact with the cancer cells and a molecule that neutralizes the cancer cells;
- and
- flowing the cancer cells on the flow surface.
A method for making a device for neutralizing cancer cells comprising the steps of
- providing a flow surface;
- coating the flow surface with an adhesive molecule that selectively interacts with the cancer cells;
- and
- coating the flow surface with a molecule that neutralizes the cancer cells.
Dependencies are inferred from the claim text.