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US 2009/0022746 A1Published application
Complexes for transferring nucleic acids into cells
OwnerJoachim Simon, Martin Vollmer +2inventors
InventorsJoachim Simon, Martin Vollmer, Ulrich Betz, Philip Scuderi
Life of this patent
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Abstract
The invention relates to complexes of cationic polymers and nucleic acids, to the use of such complexes for introducing nucleic acids into cells and organisms, to the use of the complexes as pharmaceuticals, and to novel polymers which can be used to prepare the complexes.
Claims11
Complex comprising a linear cationic polymer which is soluble or dispersible in water and has hydrophobic substituents, and at least one nucleic acid, wherein the linear catonic polymer comprises a main polymer chain,
- and wherein the polymer has the following formula:
- in which on the acyl group in each individual [CH2—CH2—N] unit
- R1 is hydrogen, methyl or ethyl, and R1 is the same in all occurrences throughout the polymer, and
- R2 is alkyl with 1 to 22 carbon atoms, and R2 is the same in all occurrences throughout the polymer;
- and in which
- R3 and R4 are, independently of one another, hydrogen or alkyl with 1 to 24 carbon atoms, or have a structure dependent on the acid initiator,
- and where
- R5 is a substituent dependent on the termination reaction, and where the average degree of polymerization P=(m+n) is in the range from 45 to 5250, and n=a×P with 0.001<a<0.1, where the units m and n are randomly distributed in the polymer.
5 more elements
2-19. (canceled)
28-33. (canceled)
Dependencies are inferred from the claim text.