US 2009/0022738 A1 · Multispecific deimmunized CD3-binders

Abstract

The present invention provides a cytotoxically active CD3 specific binding construct comprising a first domain specifically binding to human CD3 and an Ig-derived second binding domain. Furthermore, a nucleic acid sequence encoding a CD3 specific binding construct of the invention is provided. Further aspects of the invention are vectors and host cells comprising said nucleic acid sequence, a process for the production of the construct of the invention and composition comprising said construct. The invention also provides the use of said constructs for the preparation of pharmacutical compositions for the treatment of particular diseases, a method for the treatment of particular diseases and a kit comprising the binding construct of the invention.

Claims41

Dependent claims

A cytotoxically active CD3 specific binding construct comprising a first domain specifically binding to human CD3 and an Ig-derived second binding domain,

wherein said first domain is deimmunized and comprises a CDR-H1 region, a CDR-H2 region and a CDR-H3 region, said CDR-H3 region comprising an amino acid sequence as depicted in SEQ ID NO.:
96, 108, 119, 120, 121, 122, 123, 124, 125, 126, or 127;
and
wherein said first domain further comprises in its framework H1 the sequence VKK and wherein the transition sequence between framework H1 and CDRH1 region comprises the sequence Ala-Ser-Gly-Tyr-Thr-Phe (ASGYTF;
SEQ ID NO.:
233).

3 more elements

Dependencies are inferred from the claim text.

Facts

Application

10/572,740Filed 15 Oct 2004

Priority

EP 03 02 3581.616 Oct 2003

Published

22 Jan 2009

Term ends

Not estimatedThe source records don’t support an estimate.

Classification24 codes

A61P 19/02
Drugs for skeletal disorders: for joint disorders, e.g. arthritis, arthrosis
C07K 16/2896
Against receptors, cell surface antigens or cell surface determinants: against molecules with a "CD"-designation, not provided for elsewhere
A61P 29/00
Non-central analgesic, antipyretic or antiinflammatory agents
A61P 31/04
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics: antibacterial agents

Multispecific deimmunized CD3-binders

Life of this patent

Multispecific deimmunized CD3-binders

Life of this patent

Abstract

Claims41