Receptor Binding Polypeptides
AssigneeNational Health Research Institutes
InventorsPele Choi Sing Chong, Shie-Liang Hsieh
Life of this patent
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Abstract
Isolated polypeptides containing fragments of SARS CoV S protein and functional equivalents thereof. Also disclosed are isolated nucleic acids encoding the polypeptides, related expression vectors, related host cells, related antibodies, and related compositions. Methods of producing the polypeptide, diagnosing infection with a coronavirus, and identifying a test compound for treating infection with a coronavirus are also disclosed.
Claims13
1-11. (canceled)
An isolated nucleic acid comprising a sequence encoding a polypeptide or a complement thereof, wherein the polypeptide comprises SEQ ID NO:
- 4 or an immunogenic fragment thereof, and the immunogenic fragment is at least 10 amino acid residues in length.
(canceled)
A method of generating an antibody against a polypeptide, the method comprising administering to a non-human animal a polypeptide or a nucleic acid encoding the polypeptide, wherein the polypeptide comprises SEQ ID NO:
- 4 or an immunogenic fragment thereof, and the immunogenic fragment is at least 10 amino acid residues in length.
A method of inducing an immune response in a subject against a coronavirus, the method comprising administering to the subject a polypeptide or a nucleic acid encoding the polypeptide, wherein the polypeptide comprises SEQ ID NO:
- 4 or an immunogenic fragment thereof, and the immunogenic fragment is at least 10 amino acid residues in length.
21-24. (canceled)
A method of treating an infection with a coronavirus, the method comprising administering to a subject in need thereof an effective amount of a polypeptide, wherein the polypeptide comprises SEQ ID NO:
- 4 or an immunogenic fragment thereof, and the immunogenic fragment is at least 10 amino acid residues in length.
26-29. (canceled)
Dependencies are inferred from the claim text.