Method of using il6 antagonists with proteasome inhibitors
OwnerMohamed Zaki, Jeffrey Nemeth +1inventors
InventorsMohamed Zaki, Jeffrey Nemeth, Robert Z. Orlowski
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Abstract
The invention is directed to a method of treating a cancerous disorder or condition, or an IL-6related disorder or condition, in a mammal in need of such treatment, which comprises co-administering a proteasome inhibitor in combination with an IL-6antagonist
Claims19
A method of treating a cancerous disorder or condition in a mammal in need of such treatment which comprises co-administering a proteasome inhibitor in combination with an IL-6 antagonist.
A method for inhibiting tumor growth in a mammal in need thereof comprising administering to the mammal in conjunction with a proteasome inhibitor, a monoclonal antibody or fragment thereof which prevents IL6 activation of signaling through membrane bound receptors in an amount effective to inhibit the growth of said tumor.
A method for preventing metastases in a mammal comprising administering to the mammal in conjunction with a proteasome inhibitor, a monoclonal antibody or fragment thereof which prevents IL6 activation of signaling through membrane bound receptors in an amount effective to prevent metastases in said mammal.
A method of treating an IL-6 related disorder or condition, in a mammal in need of such treatment, which comprises co-administering a proteasome inhibitor in combination with an IL-6 antagonist.
Dependencies are inferred from the claim text.