Conjugate of an antibody against CD4 and antifusogenic peptides
OwnerStephan Fischer, Erhard Kopetzki +2inventors
InventorsStephan Fischer, Erhard Kopetzki, Stefan Ries, Suryanarayana Sankuratri
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Abstract
The current invention is related to a conjugate comprising two or more antifusogenic peptides and an anti-CD4 antibody (mAb CD4) characterized in that one to eight antifusogenic peptides are each conjugated to one terminus of the heavy and/or light chains of said anti-CD4 antibody and to the pharmaceutical use of said conjugate.
Claims20
A conjugate comprising two or more antifusogenic peptides and an anti-CD4 antibody, characterized in that two to eight antifusogenic peptides are each conjugated to one terminus of the heavy and/or light chains of said anti-CD4 antibody.
The antifusogenic peptide of SEQ ID NO:
- 42.
An antifusogenic conjugate, comprising a first polypeptide having the primary structure:
- [peptide-1]a-[linker-1]b-[heavy chain-1]-[linker-2]c-[peptide-2]d,
- wherein peptide-1 and peptide-2 are each independently an antifusogenic peptide;
- linker-1 and linker-2 are each independently a polypeptide linker;
- heavy chain-1 is an immunoglobulin heavy chain, or antigen-binding fragment thereof, capable of specifically binding to human CD4;
- and
- a, b, c, and d are each independently 1 or 0, wherein a and d are not simultaneously 0.
Dependencies are inferred from the claim text.