Methods of treating a blood pathology using anti-TNF antibodies and fragments thereof
AssigneesCentocor, Inc., New York University
InventorsJunming Le, Jan Vilcek, Peter Daddona, John Ghrayeb, David Knight, Scott Siegel
Life of this patent
Estimating the term…
Abstract
Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-α (TNFα) and are useful in vivo diagnosis and therapy of a number of TNFα-mediated pathologies and conditions, as well as polynucleotides coding for murine and chimeric antibodies, methods of producing the antibody, methods of use of the anti-TNF antibody, or fragment, region or derivative thereof, in immunoassays and immunotherapeutic approaches are provided.
Claims22
A method of inhibiting or neutralizing TNFα in a human patient, wherein said human patient has a vascular inflammatory pathology, comprising administering to said human patient a TNFα-inhibiting effective amount of an anti-TNFα antibody or antigen-binding fragment thereof, said antibody comprising a human constant region, wherein said anti-TNFα antibody or antigen-binding fragment (i) competitively inhibits binding of A2 (ATCC Accession No. PTA-7045) to human TNFα, and (ii) binds to human TNFα with an affinity of at least 1×108 liter/mole, measured as an association constant (Ka).
A method of inhibiting or neutralizing TNFα in a human patient, wherein said human patient has a vascular inflammatory pathology, comprising administering to said human patient a TNFα-inhibiting effective amount of an anti-TNFα antibody or antigen-binding fragment thereof, said antibody comprising a human constant region, wherein said anti-TNFα antibody or antigen-binding fragment (i) comprises the antigen-binding regions of A2 (ATCC Accession No. PTA-7045), and (ii) binds to human TNF-α with an affinity of at least 1×108 liter/mole, measured as an association constant (Ka).
A method of inhibiting or neutralizing TNFα in a human patient, wherein said human patient has a vascular inflammatory pathology, comprising administering to said human patient a TNFα-inhibiting effective amount of an anti-TNFα antibody or antigen-binding fragment thereof, said antibody comprising a human constant region, wherein said anti-TNFα antibody or antigen-binding fragment (i) has epitopic specificity identical to A2 (ATCC Accession No. PTA-7045), and (ii) binds to human TNF-α with an affinity of at least 1×108 liter/mole, measured as an association constant (Ka).
Dependencies are inferred from the claim text.