Combination methods of inhibiting tumor growth with a vascular endothelial growth factor receptor antagonist
AssigneeImClone Systems Incorporated
InventorsPatricia Rockwell, Neil I. Goldstein
Life of this patent
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Abstract
The present invention provides a method of reducing or inhibiting tumor growth in a mammal comprising treating the mammal with an effective amount of a combination of a VEGF receptor antagonist and radiation, chemotherapy, and/or an additional receptor antagonist.
Claims19
A method of inhibiting tumor growth comprising administering to a human a therapeutically effective amount of a vascular endothelial growth factor receptor (VEGFR) antibody or functional equivalent thereof that specifically binds to VEGFR and inhibits binding of a ligand thereto and a therapeutically effective amount of a separate epidermal growth factor receptor (EGFR) antibody or functional equivalent thereof that specifically binds to EGFR and inhibits binding of ligand thereto.
A kit for inhibiting tumor growth comprising a therapeutically effective amount of an epidermal growth factor receptor (EGFR) antibody or functional equivalent thereof that specifically binds to EGFR and inhibits binding of a ligand thereto and a therapeutically effective amount of a separate vascular endothelial growth factor receptor (VEGFR) antibody or functional equivalent thereof that specifically binds to VEGFR and inhibits binding of a ligand thereto.
Dependencies are inferred from the claim text.