Compositions and Methods for Inhibiting Leukocyte Function
AssigneeUniversity of Virginia Patent Foundation
InventorsJoerg Reutershan, Martin A. Schwartz, Klaus F. Ley, Rebecca A. Stockton
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Abstract
The present invention provides compositions and methods for regulating leukocyte migration and function. The present invention also provides compositions and methods for preventing and inhibiting lung injury and damage associated with neutrophil infiltration of the lung.
Claims26
A method of inhibiting leukocyte function, said method comprising contacting said leukocyte with an effective amount of at least one inhibitor of a protein regulatory pathway selected from the group consisting of PAK and PIX regulatory pathways, thereby inhibiting leukocyte function.
A method of treating a disease or disorder associated with increased leukocyte infiltration or activity in a subject in need thereof, said method comprising administering to said subject a pharmaceutical composition comprising an effective amount of at least one inhibitor of a protein regulatory pathway selected from the group consisting of PAK and PIX regulatory pathways, thereby treating a disease or disorder associated with increased leukocyte infiltration or activity.
A kit for administering a compound which inhibits a disease or disorder associated with increased leukocyte infiltration or activity, said kit comprising a pharmaceutical composition comprising at least one inhibitor of a protein regulatory pathway selected from the group consisting of PAK and PIX regulatory pathways, an applicator, and an instructional material for the use thereof.
A method for identifying a compound that inhibits PAK or PIX regulated function of leukocytes, wherein said compound inhibits at least one protein regulatory pathway selected from the group consisting of PAK and PIX, said method comprising:
- contacting a test leukocyte comprising at least one of said regulatory pathways with a test compound;
- measuring the activity or function of at least one of said regulatory pathways,
- wherein a lower level of said activity or function in the test leukocyte, compared with the level of activity or function in an otherwise identical leukocyte not contacted with said test compound, is an indication that said test compound inhibits leukocyte function.
Dependencies are inferred from the claim text.