Control of sorbose utilization genes and uses thereof
OwnerElena Rustchenko Bulgac, M. Anaul Kabirinventors
Life of this patent
Estimating the term…
Abstract
This invention relates generally to the discovery of a novel control of sorbose utilization (CSU) genes. The invention further relates to the detection of these genes and their use in the diagnosis and treatment of fungal infections.
Claims71
A purified polypeptide comprising an amino acid sequence at least about 95% identical to the sequence of SEQ ID NO:
- 6.
6-10. (canceled)
13-16. (canceled)
22-25. (canceled)
28-30. (canceled)
A method of inhibiting Candida albicans cell growth comprising administering to the cell an agent that reduces CSU52 expression.
A purified polypeptide comprising an amino acid sequence at least about 95% identical to the sequence of SEQ ID NO:
- 7.
(canceled)
39-45. (canceled)
47-54. (canceled)
57-59. (canceled)
62-63. (canceled)
A method of inhibiting Candida albicans cell growth comprising administering to the cell an agent that reduces CSU53 expression.
67-68. (canceled)
A purified polypeptide comprising an amino acid sequence at least about 95% identical to the sequence of SEQ ID NO:
- 8.
(canceled)
73-79. (canceled)
81-88. (canceled)
90-93. (canceled)
(canceled)
(canceled)
A method of inhibiting Candida albicans cell growth comprising administering to the cell an agent that reduces CSU55 expression.
101-102. (canceled)
A purified polypeptide comprising an amino acid sequence at least about 95% identical to the sequence of SEQ ID NO:1.
(canceled)
107-125. (canceled)
A method of reducing CSU51 expression in a cell comprising administering to the cell an antisense oligonucleotide that specifically binds to mRNA transcribed from the CSU51 gene under conditions that allow hybridization, wherein the CSU51 mRNA comprises SEQ ID NO:
- 2.
127-128. (canceled)
(canceled)
(canceled)
A method of inhibiting Candida albicans cell growth comprising administering to the cell an agent that reduces CSU51 expression.
136-137. (canceled)
Dependencies are inferred from the claim text.