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US 2009/0022684 A1Published application
Methods for hematopoietic stimulation
OwnerPaul Morleyinventor
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OwnerPaul Morleyinventor
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The present invention is directed to new methods for treating a subject in need of hematopoietic stimulation. The present invention is also directed to new methods of neutrophil stimulation in a subject in need thereof. The present invention is also directed to new methods of platelet stimulation in a subject in need thereof. The methods comprise administering to the subject an effective amount of a peptide optionally in combination of a hematopoietic growth factor, wherein the peptide is: (i) Ser-Val-Ser-Glu-Ile-Gln-Leu-Met-His-Asn-Leu-Gly-Lys-His-Leu-Asn-Ser-Met-Glu-Arg-Val-Glu-Trp-Leu-Arg-Lys-Xaa-Leu-Gln-Asp-Val-NH2 (SEQ ID NO: 1), where Xaa=Lys, Leu, Ile, Nle or Met, preferably Xaa=Lys; or (ii) Ser-Val-Ser-Glu-Ile-Gln-Leu-Met-His-Asn-Leu-Gly-Lys-His-Leu-Asn-Ser-Met-Glu-Arg-Val-Glu-Trp-Leu-Arg-Lys-Xaa-Leu-Gln-Asp-Val-Y (SEQ ID NO: 2), cyclized in the form of a lactam between Glu22 and Lys26, Xaa=Leu, Ile, Nle or Met, Y=NH2 or OH. Preferably, Xaa is Leu and Y is NH2.
A method of treating a subject in need of hematopoietic stimulation, comprising the step of administering to said subject an effective amount of a peptide optionally in combination with an effective amount of a hematopoietic growth factor, wherein the peptide is:
A method of neutrophil stimulation in a subject in need thereof, comprising the step of administering to said subject an effective amount of a peptide optionally in combination with an effective amount of a hematopoietic growth factor, wherein the peptide is:
The method of 49, wherein Xaa=Lys.
61 The method of claim 46, wherein the subject in need of neutrophil stimulation is administered an effective amount of the peptide that results in the maximum plasma concentration of the peptide in the range of 100 pg/mL to 150 pg/mL.
A method of platelet stimulation in a subject in need thereof, comprising the step of administering to said subject an effective amount of a peptide optionally in combination with an effective amount of a hematopoietic growth factor, wherein the peptide is:
The method of 94, wherein Xaa=Lys.
Dependencies are inferred from the claim text.