US 2009/0022663 A1 · ANTIBODIES AND RELATED MOLECULES THAT BIND TO 161P2F10B PROTEINS

Abstract

Antibodies and molecules derived therefrom that bind to 161P2F10B protein and variants thereof, are described wherein 161P2F10B exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 161P2F10B provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 161P2F10B gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 161P2F10B can be used in active or passive immunization.

Claims28

Dependent claims

A method of delivering a cytotoxic agent to a cell that expresses a 161P2F10B protein comprising the amino acid sequence of SEQ ID NO:2, comprising:

providing a cytotoxic agent, wherein the cytotoxic agent comprises a monoclonal antibody or fragment thereof comprising an antigen binding site that binds specifically to 161P2F10B protein comprising the amino acid sequence of SEQ ID NO:2, and wherein the monoclonal antibody comprises the VH region of SEQ ID NO:139, from residue 1 to 114 and the VL region of SEQ ID NO:140, from residue 1 to 108 and a cytotoxin, wherein the antibody or fragment thereof is conjugated to the cytotoxin;
and
delivering the cytotoxic agent to the cell.

Dependencies are inferred from the claim text.

Facts

Application

12/196,039Filed 21 Aug 2008

Priority

31 Mar 2005

Published

22 Jan 2009

Term ends

Not estimatedThe source records don’t support an estimate.

Classification10 codes

C07K 16/30
Against receptors, cell surface antigens or cell surface determinants: from tumour cells
A61P 31/00
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
A61P 35/00
Antineoplastic agents
A61P 43/00
Drugs for specific purposes, not provided for in groups a61p1/00-a61p41/00

Family

Application60/667,588Us provisional application · filed 31 Mar 2005

Application60/700,975Us provisional application · filed 20 Jul 2005

Application11/396,178Division · filed 31 Mar 2006

Application12/196,039Division

US 2006/0275211 A1Published application

US 7,427,399 B2Related patent

US 2009/0022663 A1This patent

From the US filing history. Foreign family members aren’t listed.

Antibodies and related molecules that bind to 161p2f10b proteins

Life of this patent

Antibodies and related molecules that bind to 161p2f10b proteins

Life of this patent

Abstract

Claims28