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AssigneeAlderbio Holdings LLC
InventorsKatie Olson, Ben Dutzar, Anne Elisabeth Carvalho Jensen, Leon Garcia - Martinez, Ethan Ojala, John Latham
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The present invention is directed to antibodies and fragments thereof having binding specificity for TNF-α. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the VH, VL and CDR polypeptides described herein, and the polynucleotides encoding them. The invention also contemplates conjugates of anti-TNF-α antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. The invention also contemplates methods of making said anti-TNF-α antibodies and binding fragments thereof. Embodiments of the invention also pertain to the use of anti-TNF-α antibodies, and binding fragments thereof, for the diagnosis, assessment and treatment of diseases and disorders associated with TNF-α.
An anti-human TNF-α antibody or antibody fragment which specifically binds to the same linear or conformational epitope(s) and/or competes for binding to the same linear or conformational epitope(s) on an intact human TNF-α polypeptide or fragment thereof as an anti-human TNF-α antibody selected from the group consisting of Ab1, Ab2, Ab3, Ab4, Ab5, Ab6, Ab7, Ab8, Ab9, Ab10, Ab11, Ab12, Ab13, Ab14, Ab15, Ab16, Ab17, Ab18, Ab19, Ab20, Ab21, Ab22, Ab23, Ab24, Ab25, and Ab26.
An isolated anti-TNF-α antibody comprising a VH polypeptide sequence selected from the group consisting of:
An isolated polynucleotide comprising a polynucleotide encoding an anti-TNF-α VH antibody amino acid sequence selected from SEQ ID NO:
An isolated polynucleotide comprising the polynucleotide sequence encoding an anti-TNF-α VL antibody amino acid sequence of 2, 18, 34, 50, 66, 82, 98, 114, 130, 146, 162, 178, 194, 210, 226, 242, 258, 274, 290, 306, 322, 338, 354, 370, 386 and SEQ ID NO:
An isolated anti-TNF-α antibody or antibody fragment comprising one or more of the CDRs contained in the VH polypeptide sequences selected from the group consisting of:
The antibody of claim 97, wherein the primate is Macaca fascicularis.
An isolated polynucleotide that expresses a polypeptide containing at least one CDR polypeptide derived from an anti-TNF-α antibody wherein said expressed polypeptide alone specifically binds TNF-α or specifically binds TNF-α when expressed in association with another polynucleotide sequence that expresses a polypeptide containing at least one CDR polypeptide derived from an anti-TNF-α antibody wherein said at least one CDR is selected from those contained in the VL or VH polypeptides contained in SEQ ID NO:
Dependencies are inferred from the claim text.