Modified antibodies and methods of use
OwnerGary R. Braslawsky, Nabil Hanna +1inventors
InventorsGary R. Braslawsky, Nabil Hanna, Paul Chinn
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Abstract
Novel compounds, compositions and methods comprising modified antibodies are provided. In preferred embodiments the disclosed modified antibodies comprise antibodies having one or more of the constant region domains altered or deleted to afford beneficial physiological properties such as enhanced target localization and rapid blood clearance. The disclosed compounds are particularly useful for the treatment of neoplastic disorders in myelosuppressed patients.
Claims35
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A domain deleted C2B8 antibody reactive with CD20 comprising a heavy chain having an amino acid sequence substantially as set forth in FIG. 1B.
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A method of treating a myelosuppressed patient suffering from a neoplastic disorder comprising the step of administering a therapeutically effective amount of a modified antibody to said patient.
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A method of treating a patient exhibiting a neoplastic disorder comprising the steps of:
- administering a therapeutically effective amount of at least one chemotherapeutic agent to said patient;
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- administering a therapeutically effective amount of at least one modified antibody to said patient wherein said chemotherapeutic agent and said modified antibody may be administered in any order or concurrently.
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Dependencies are inferred from the claim text.