Metered dose inhaler actuator

Abstract

Metered dose inhaler actuators for pressurised aerosol containing a formulation of at least one medicament in a liquefied propellant gas which comprise: a nozzle block 5 having a bore 11 to receive a valve stem 7; a sump 8 in connection with a bore 11, wherein the propellant formulation expands upon actuation of the inhaler; a nozzle channel 6, exiting from the sump 8 and aligned with a mouthpiece 4, wherein the sump 8 has an internal volume between 2 and 12 mm3 prevent the deposition of the medicament during the delivery into the chamber and/or into the nozzle channel. a reduction in the delivered dose, and an increase in the occurrence of the clogging of the inhaler. Such actuators are particularly useful for the administration of pressurised metered dose inhaler formulations, in solution and/or in suspension, wherein the concentration of the active ingredient(s) of the formulation is/are particularly high and in particular suitable to administer at least 100 μg/dose, preferably at least 200 μg/dose, even more preferably at least 400 μg/dose.

Dependencies are inferred from the claim text.