Combination Therapy with Triterpenoid Compounds and Proteasome Inhibitors
AssigneeResearch Development Corporation
InventorsJordan Gutterman, Amos Gaikwad, Ann Poblenz, Valsala Haridas
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Abstract
The present invention provides therapeutic compositions comprising a natural triterpenoid and a proteasome inhibitor. These compositions will be particularly useful in the treatment of malignancies and inflammation. The present invention also provides methods of treating a subject having a malignancy or an inflammatory disorder comprising administering to the subject a natural triterpenoid and a proteasome inhibitor.
Claims47
A method of inducing apoptosis in a malignant cell comprising contacting the malignant cell with a natural triterpenoid and a proteasome inhibitor.
A method treating a subject with a malignancy comprising administering to said subject a natural triterpenoid and a proteasome inhibitor.
A method treating a subject with an inflammatory disorder comprising administering to said subject a natural triterpenoid and a proteasome inhibitor.
A pharmaceutical composition comprising a natural triterpenoid and a proteasome inhibitor in a pharmacologically acceptable buffer, solvent or diluent.
A method of treating cell proliferative disease in a subject comprising, administering an effective amount of a natural triterpenoid compound and an effective amount of a proteasome inhibitor.
The method of claim, 43 wherein the proteasome inhibitor is PS341 (bortezomib).
Dependencies are inferred from the claim text.