Devices, systems, and methods for measuring glucose
OwnerJohn R. Williams, Angela M. Zapata +1inventors
InventorsJohn R. Williams, Angela M. Zapata, Nina Mahealani Heinrich
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Abstract
Systems and methods for detecting glucose in a sample using, for example, a regenerable sensor are described. The sensor may, for example, include boronic acid to detect with great sensitivity and at a low cost the glucose in the sample.
Claims27
A regenerable sensor for measuring glucose in a sample, comprising:
- a diaphragm comprising a conductive portion;
- a molecular receptor, capable of reversibly binding to the glucose, coated on a first face of the diaphragm;
- and
- a counterelectrode spaced from and in opposition to the diaphragm, wherein the diaphragm deforms and thereby alters a capacitance of the regenerable sensor upon binding of the glucose to the molecular receptor.
A method for measuring glucose in a sample, the method comprising:
- exposing the sample to a sensor that comprises boronic acid bound to a moveable surface of the sensor;
- measuring the glucose reversibly bound to the boronic acid;
- and
- following the measuring, regenerating the moveable surface by removing the glucose bound to the boronic acid.
A method for determining an amount of glucose in a sample that comprises the glucose and an interfering compound, the method comprising:
- exposing the sample to a first sensor comprising a first molecular receptor capable of binding the glucose and the interfering compound;
- exposing the sample to a second sensor comprising a second molecular receptor capable of binding the glucose and the interfering compound, the second molecular receptor having a different binding constant than the first molecular receptor for at least one of the glucose and the interfering compound;
- measuring a total amount of glucose and interfering compound bound to each of the first molecular receptor and the second molecular receptor;
- and
- based thereon, calculating the amount of glucose in the sample.
A system for determining an amount of glucose in a sample that comprises the glucose and an interfering compound, the system comprising:
- a first sensor comprising a first surface having separate binding constants for each of the glucose and the interfering compound;
- and
- a second sensor comprising a second surface having separate binding constants for each of the glucose and the interfering compound, at least one binding constant for the second surface being different from the corresponding binding constant for the first surface.
A ligand for use in a glucose sensor, the ligand comprising the chemical structure
A ligand for use in a glucose sensor, the ligand comprising the chemical structure
Dependencies are inferred from the claim text.