Imaging Infection With Compounds That Bind to Thymidine Kinase
AssigneeThe John Hopkins University
InventorsMartin G. Pomper, Chetan Bettegowda, Catherine Foss, Shibin Zhou, Kenneth Kinzler, Bert Vogelstein
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Abstract
The instant invention provides a method for diagnosing an infection in a subject by administering to the subject a compound suitable for imaging which binds to a thymidine kinase present in the infecting organism, and obtaining an image of the subject to determine the presence and location of the compound, wherein a localization of the compound is indicative that the subject has an infection.
Claims40
A method for diagnosing an infection in a subject comprising:
- administering to the subject a compound suitable for imaging which binds to a thymidine kinase present in the infecting organism;
- and
- obtaining an image of the subject to determine the presence and location of the compound;
- wherein a localization of the compound is indicative that the subject has an infection.
A method for imaging a bacterial infection in a subject comprising:
- administering to the subject a compound suitable for imaging which binds to a bacterial thymidine kinase;
- and
- obtaining an image of the subject;
- thereby obtaining an image of the bacterial infection in a subject.
A method for monitoring the efficacy of treatment in a subject having an infection comprising:
- administering to the subject a first dose of a compound suitable for imaging which binds to a thymidine kinase present in the infecting organism;
- obtaining a first image of the subject to determine the presence and location of the compound;
- administering to the subject a second dose of a compound suitable for imaging which binds to a thymidine kinase present in the infecting organism at a time subsequent to the first administration;
- and
- obtaining a second image of the subject to determine the presence and location of the compound;
- wherein a decrease in amount of compound localized to a particular location is indicative of effective therapy.
A method for imaging bacterial-based anticancer therapy comprising:
- administering to a subject a compound suitable for imaging which binds to a thymidine kinase present in a therapeutic bacteria;
- and
- imaging the subject to determine the presence and location of the compound;
- thereby imaging a bacterial-based anticancer therapy.
The method of claim 365, wherein the nucleoside analog emits gamma particles.
Dependencies are inferred from the claim text.