Inhibitors of Matrix Metallaproteinases

A compound of formula I:

• wherein
• R1 is (C1-C6)alkyl, halo(C1-C6)alkyl, (C1-C6)alkoxy, aryl(C1-C6)alkyl, heteroaryl(C1-C6)alkyl, aryl(C1-C6)alkoxy, heteroaryl(C1-C6)alkoxy, aryl, heteroaryl, hydroxy, SR5, NR5R5, or absent;
• R2 is CH2, carbonyl, SO2, or OH;
• L is CH2, NR5, or O;
• R3 and R4 are each independently hydroxy, (C1-C6)alkyl, (C1-C6)alkoxy, (C1-C6)alkanoyl, (C1-C6)alkanoyloxy, aryl, heteroaryl, carboxy, cyano, nitro, halo, trifluoromethyl, trifluoromethoxy, SR5, SO2N(R5)2, NR5R5, or CO2R5;
• each n is independently 0 to 4;
• each R5 is independently H, (C1-C6)alkyl, (C1-C6)alkanoyl, (C6-C10)aroyl, aryl, aryl(C1-C6)alkyl, heteroaryl, heteroaryl(C1-C6)alkyl, or a nitrogen protecting group;
• X is O, S, SO, SO2, CH2—O, CH2—S, CH2—NR5, NR5, carbonyl, or a direct bond;
• D is S, SO, SO2, C═N—OH, or carbonyl;
• E is a direct bond, or (C1-C6)alkyl;
• J is S, O, or NR5;
• G, T, and Q are each independently H, (C1-C6)alkyl, or cyano;
• any alkyl, amino, aryl, heteroaryl, or cycloalkyl is optionally substituted with 1 to about 5 (C1-C6)alkyl, (C1-C6)alkoxy, aryl, heteroaryl, aryl(C1-C6)alkyl, heteroaryl(C1-C6)alkyl, nitro, halo, amino, or hydroxy groups;
• or a pharmaceutically acceptable salt thereof;
• provided that when L is CH2 or O, and R2 is CH2, R1 is not (C1-C6)alkyl;
• when L is O and R2 is carbonyl, R1 is not (C1-C6)alkyl;
• and
• when L is NR5, R2 is not CH2.